How Some Dogs Get Cancer: How Genetic Mutations Trigger Cancer in Dogs | Charlotte Hacker, MS, PhD #286
Why do dogs get cancer, and how do genetics play a role? Dr. Charlotte Hacker explains the impact of mutations and breeding on cancer in dogs.
Dr. Charlotte Hacker discusses the complex genetics behind why dogs get cancer. Despite common beliefs, larger animals like elephants and blue whales rarely get cancer due to high levels of tumor suppressor genes like p53. Unfortunately, dogs' genetic makeup, influenced by rapid, human-directed breeding practices, makes them particularly susceptible to cancer.
Dr. Hacker explains the role of DNA, mutations, proto-oncogenes, and tumor suppressor genes in cancer development. She emphasizes variability across breeds, hereditary and spontaneous mutations, and environmental factors like UV light. Preventive measures for genetic and spontaneous mutations in dogs, common cancer-related genes in different breeds, and the promise of emerging research in fields like epigenetics are also discussed.
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Related Videos:
https://www.youtube.com/watch?v=Q7Wvo9IjcvA
https://www.youtube.com/watch?v=VlkWnaCYvfU
Related Links:
Genetic Mutations and Dog Cancer: An Overview (article) https://www.dogcancer.com/articles/stats-and-facts/genetic-mutations-and-dog-cancer/
Chapters:
00:00 Introduction
00:21 Meet Dr. Charlotte Hacker
01:09 Understanding Dog Genetics
03:06 DNA and Its Role in Cancer
06:48 Mutations and Their Effects
18:43 Oncogenes and Tumor Suppressors
24:14 Preventing Mutations in Dogs
25:49 Conclusion and Resources
33:55 Closing Remarks and Resources
Get to know Charlotte Hacker:
https://www.dogcancer.com/people/charlotte-hacker-ms-phd/
For more details, articles, podcast episodes, and quality education, go to the episode page: https://www.dogcancer.com/podcast/
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