Summary:
Veterinary oncologists are using the drug Palladia for dogs with many types of cancer now. Dr. Megan Duffy explains why.
Notes:
Is Palladia safe? Does it have a lot of side effects? Does giving my dog a cancer drug at home multiple times a week make my dog “toxic”? Can my dog with other health problems take this drug safely?
Palladia was approved for dogs with high-grade mast cell tumors in dogs over a decade ago. But since then, veterinary oncologists have started using it in many solid tumor types. They’ve also tweaked the doses to lessen the risk of side effects.
Veterinary oncologist Dr. Megan Duffy joins us for an in-depth look at this “kind of weird, exciting drug.” She explains a little about how it works, when it is used, and answers ALL the questions that came up in our Facebook Dog Cancer Support Group about this drug.
If your veterinarian wants to start your dog on Palladia, and you’re wondering why … this is a must-watch video for you because Dr. Duffy has advice about how to know if Palladia might help YOUR dog’s case.
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Related Videos:
Our first show on Palladia many years ago: https://www.youtube.com/watch?v=ShOzhnd-Hw4
Chemotherapy for Dogs Demystified: https://www.youtube.com/watch?v=V6_fWtQbxfw
A wonderful show about how Regular Veterinarians Can Offer Chemotherapy: https://www.youtube.com/watch?v=1izf0aw-cr4
Related Links:
Our DogCancer.com article on Palladia: https://www.dogcancer.com/articles/drugs/palladia-for-dogs/
Our DogCancer.com article about whether chemotherapy for dogs is worth doing: https://www.dogcancer.com/articles/drugs/dog-chemotherapy/
Dr. Duffy mentioned using Palladia at the same time as metronomic chemotherapy. Here’s our DogCancer.com article about that: https://www.dogcancer.com/articles/diagnosis-and-medical-procedures/metronomic-chemotherapy-for-dogs/
Chapters:
00:00 Welcome to Dog Cancer Answers
01:20 Palladia’s Effectiveness for Uncommon Tumor Types in Dogs
02:13 Palladia is labeled for mast cell tumors, but it can also be used in carcinomas, endocrine tumors … and even in cats!
02:52 Why choose Palladia for “weird” tumors that don’t have standard treatment options.
03:30 Is Palladia a chemotherapy drug? Not technically. It’s an antiangiogenic anti-cancer drug.
04:48 Palladia is taken at home, which opens up cancer treatment to more patients.
05:52 Common dosing schedules for Palladia for dogs: Monday, Wednesday, Friday.
06:25 How long dogs stay on Palladia – the million dollar question!
07:38 How much does Palladia cost? It depends upon several factors.
08:40 Does Palladia cure cancer in dogs?
09:25 Does Palladia help with metastasis after surgery?
09:59 When Palladia is used “off-label” how do veterinary oncologists know to use it?
11:48 Palladia’s a pioneering targeted anti-cancer drug. Is it being used in anything other than cancer cases?
12:20 Dr. Megan Duffy provides medical review for DogCancer.com, better information today, for no regrets tomorrow, where you can do your own research safely.
14:43 How to give Palladia at home: with food? Gloved?
16:18 Handling Palladia Safely: Precautions for toxicity and rapidly dividing cells in pregnant women and children.
17:32 Cleaning up poop and pee when your dog is on Palladia.
19:25 Is it safe to play with and cuddle your dog when they’re on Palladia?
19:54 Is it safe to let your dog on Palladia lick you?
21:00 How often do you see your veterinarian while using Palladia? What tests do veterinarians use to monitor health with Palladia use?
22:56 What are common Palladia side effects, and how soon do they start?
23:52 Using Palladia for two weeks before committing to long-term use.
24:14 What percentage of dogs aren’t compatible with Palladia?
24:40 Lack of appetite, vomiting, and diarrhea in 20% of dogs on Palladia and how to help them.
26:15 How do I assess if my dog is a good fit for Palladia?
26:45 The history of dosing for Palladia, including the original labeled maximum tolerated and current biologically effective doses.
28:30 How the small community of veterinary oncologists talk to each other to reach a consensus.
30:08 Do the side effects stop if my dog stops taking Palladia?
37:46 Questions should I ask my veterinarian about Palladia?
38:52 Dr. Duffy’s predictions about take-home anti-cancer medications for dog cancer.
40:20 Dr. Duffy discusses companies that sequence genomes for dog cancer tumors.
41:48 Dr. Duffy’s parting thoughts on Palladia.
42:14 James Jacobson’s parting words.
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Get to know Megan Duffy, DVM, ACVIM (Oncology): https://www.dogcancer.com/people/megan-duffy-dvm-acvim-oncology/
For more details, articles, podcast episodes, and quality education, go to the episode page: https://www.dogcancer.com/podcast/
